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Global Epigenomic Reconfiguration During Mammalian Brain Development

2013; American Association for the Advancement of Science; Volume: 341; Issue: 6146 Linguagem: Inglês

10.1126/science.1237905

1095-9203

Ryan Lister, Eran A. Mukamel, Joseph R. Nery, Mark A. Urich, Clare A. Puddifoot, Nicholas D. Johnson, Jacinta Lucero, Yun Huang, Andrew J. Dwork, Matthew D. Schultz, Miao Yu, Julian Tonti‐Filippini, Holger Heyn, Shijun Hu, Joseph C. Wu, Anjana Rao, Manel Esteller, Chuan He, Fatemeh Haghighi, Terrence J. Sejnowski, M. Margarita Behrens, Joseph R. Ecker,

Genetics and Neurodevelopmental Disorders

Epigenetic Brainscape Epigenetic modifications and their potential changes during development are of high interest, but few studies have characterized such differences. Lister et al. ( 1237905 , published online 4 July; see the Perspective by Gabel and Greenberg ) report whole-genome base-resolution analysis of DNA cytosine modifications and transcriptome analysis in the frontal cortex of human and mouse brains at multiple developmental stages. The high-resolution mapping of DNA cytosine methylation (5mC) and one of its oxidation derivatives (5hmC) at key developmental stages provides a comprehensive resource covering the temporal dynamics of these epigenetic modifications in neurons compared to glia. The data suggest that methylation marks are dynamic during brain development in both humans and mice.