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No Major Schizophrenia Locus Detected on Chromosome 1q in a Large Multicenter Sample

2002; American Association for the Advancement of Science; Volume: 296; Issue: 5568 Linguagem: Inglês

10.1126/science.1069914

1095-9203

Douglas F. Levinson, Peter Holmans, Claudine Laurent, Brien P. Riley, Ann E. Pulver, Pablo V. Gejman, Sibylle G. Schwab, Nigel Williams, Michael J. Owen, Dieter B. Wildenauer, Alan R. Sanders, Gerald Nestadt, Bryan Mowry, Brandon Wormley, Stéphanie Bauché, Stéphane Soubigou, R. Ribble, Deborah A. Nertney, Kung Yee Liang, L Martinolich, Wolfgang Maier, Nadine Norton, Hywel Williams, Margot Albus, Eric B. Carpenter, Nicola DeMarchi, Kelly R. Ewen-White, Dermot Walsh, Maurice Jay, Jean-François Deleuze, F. Anthony O’Neill, George N. Papadimitriou, Ann N. Weilbaecher, Bernard Lerer, Michael O’Donovan, Dimitris Dikeos, Jeremy M. Silverman, Kenneth S. Kendler, Jacques Mallet, Raymond R. Crowe, Marilyn K. Walters,

Genetic Associations and Epidemiology

Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.