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The Structure of Haplotype Blocks in the Human Genome

2002; American Association for the Advancement of Science; Volume: 296; Issue: 5576 Linguagem: Inglês

10.1126/science.1069424

1095-9203

Stacey Gabriel, S. F. Schaffner, Huy Nguyen, Jamie Moore, Jessica Roy, Brendan Blumenstiel, John M. Higgins, Matthew DeFelice, Amy L. Lochner, Maura Faggart, Shau Neen Liu-Cordero, Charles N. Rotimi, Adebowale Adeyemo, Stephen S. Rich, Ryk Ward, Eric S. Lander, Mark J. Daly, David Altshuler,

Gene expression and cancer classification

Haplotype-based methods offer a powerful approach to disease gene mapping, based on the association between causal mutations and the ancestral haplotypes on which they arose. As part of The SNP Consortium Allele Frequency Projects, we characterized haplotype patterns across 51 autosomal regions (spanning 13 megabases of the human genome) in samples from Africa, Europe, and Asia. We show that the human genome can be parsed objectively into haplotype blocks: sizable regions over which there is little evidence for historical recombination and within which only a few common haplotypes are observed. The boundaries of blocks and specific haplotypes they contain are highly correlated across populations. We demonstrate that such haplotype frameworks provide substantial statistical power in association studies of common genetic variation across each region. Our results provide a foundation for the construction of a haplotype map of the human genome, facilitating comprehensive genetic association studies of human disease.