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Engineering Enhanced Protein Stability through β‐Turn Optimization: Insights for the Design of Stable Peptide β‐Hairpin Systems

2005; Wiley; Volume: 44; Issue: 31 Linguagem: Inglês

10.1002/anie.200500577

1521-3773

Emma R. Simpson, Jill K. Meldrum, Roger Bofill, Maria D. Crespo, Elizabeth Holmes, Mark S. Searle,

RNA and protein synthesis mechanisms

One good turn: β-Turns are an important component of protein structure and nucleation sites for β-hairpin folding. With ubiquitin as a “host” system (see structure), protein engineering methods have been used to determine the energetic contribution of type I′ β-turns to the stability of proteins, with a view to optimizing the rational design of model peptide systems.