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Long-range chromosomal interactions and gene regulation

2008; Royal Society of Chemistry; Volume: 4; Issue: 11 Linguagem: Inglês

10.1039/b803580f

1742-206X

A.E. Miele, Job Dekker,

Gene expression and cancer classification

Over the last few years important new insights into the process of long-range gene regulation have been obtained. Gene regulatory elements are found to engage in direct physical interactions with distant target genes and with loci on other chromosomes to modulate transcription. An overview of recently discovered long-range chromosomal interactions is presented, and a network approach is proposed to unravel gene-element relationships.