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Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers☆

2008; Elsevier BV; Volume: 60; Issue: 11 Linguagem: Inglês

10.1016/j.addr.2008.03.012

1872-8294

Igor I. Slowing, Juan L. Vivero‐Escoto, Kevin C.‐W. Wu, Victor S.-Y. Lin,

RNA Interference and Gene Delivery

In this review, we highlight the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers. The synthesis of this type of MSN materials is described along with the current methods for controlling the structural properties and chemical functionalization for biotechnological and biomedical applications. We summarized the advantages of using MSN for several drug delivery applications. The recent investigations of the biocompatibility of MSN in vitro are discussed. We also describe the exciting progress on using MSN to penetrate various cell membranes in animal and plant cells. The novel concept of gatekeeping is introduced and applied to the design of a variety of stimuli-responsive nanodevices. We envision that these MSN-based systems have a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents.