Portal de Periódicos da CAPES

CGHAnalyzer: a stand-alone software package for cancer genome analysis using array-based DNA copy number data

2005; Oxford University Press; Volume: 21; Issue: 15 Linguagem: Inglês

10.1093/bioinformatics/bti500

1367-4811

Adam A. Margolin, Joel Greshock, Tara L. Naylor, Yaël P. Mossé, John M. Maris, Graham R. Bignell, Alexander I. Saeed, John Quackenbush, Barbara Weber,

Cancer Genomics and Diagnostics

Abstract Summary: This synopsis provides an overview of array-based comparative genomic hybridization data display, abstraction and analysis using CGHAnalyzer, a software suite, designed specifically for this purpose. CGHAnalyzer can be used to simultaneously load copy number data from multiple platforms, query and describe large, heterogeneous datasets and export results. Additionally, CGHAnalyzer employs a host of algorithms for microarray analysis that include hierarchical clustering and class differentiation. Availability: CGHAnalyzer, the accompanying manual, documentation and sample data are available for download at http://acgh.afcri.upenn.edu. This is a Java-based application built in the framework of the TIGR MeV that can run on Microsoft Windows, Macintosh OSX and a variety of Unix-based platforms. It requires the installation of the free Java Runtime Environment 1.4.1 (or more recent) (http://www.java.sun.com). Contact: weberb@mail.med.upenn.edu