Spatial analysis of amyotrophic lateral sclerosis in Northern New England, USA, 1997-2009
2012; Wiley; Volume: 48; Issue: 2 Linguagem: Inglês
10.1002/mus.23761
ISSN1097-4598
AutoresTracie A. Caller, Jonathan Chipman, Nicholas C. Field, Elijah W. Stommel,
Tópico(s)Prion Diseases and Protein Misfolding
ResumoMuscle & NerveVolume 48, Issue 2 p. 235-241 Research Article Spatial analysis of amyotrophic lateral sclerosis in Northern New England, USA, 1997–2009 Tracie A. Caller MD, Corresponding Author Tracie A. Caller MD Department of Neurology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, New Hampshire, 03753 USACorrespondence to: T. Caller; e-mail: [email protected].Search for more papers by this authorJonathan W. Chipman PhD, Jonathan W. Chipman PhD Department of Geography, Dartmouth College, Hanover, New Hampshire, USASearch for more papers by this authorNicholas C. Field BS, Nicholas C. Field BS Department of Neurology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, New Hampshire, 03753 USASearch for more papers by this authorElijah W. Stommel MD, PhD, Elijah W. Stommel MD, PhD Department of Neurology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, New Hampshire, 03753 USASearch for more papers by this author Tracie A. Caller MD, Corresponding Author Tracie A. Caller MD Department of Neurology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, New Hampshire, 03753 USACorrespondence to: T. Caller; e-mail: [email protected].Search for more papers by this authorJonathan W. Chipman PhD, Jonathan W. Chipman PhD Department of Geography, Dartmouth College, Hanover, New Hampshire, USASearch for more papers by this authorNicholas C. Field BS, Nicholas C. Field BS Department of Neurology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, New Hampshire, 03753 USASearch for more papers by this authorElijah W. Stommel MD, PhD, Elijah W. Stommel MD, PhD Department of Neurology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, New Hampshire, 03753 USASearch for more papers by this author First published: 14 December 2012 https://doi.org/10.1002/mus.23761Citations: 28Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL ABSTRACT Introduction An environmental trigger of sporadic amyotrophic lateral sclerosis (ALS) is supported by geographic disparities in ALS incidence and development of the disease in conjugal couples. This study aims to investigate the incidence of ALS in the Northern New England states of New Hampshire (NH), Vermont (VT), and Maine (ME). Methods We reviewed medical records and community databases to identify dwelling addresses of 688 patients diagnosed with ALS in 1997–2009 in NH, VT, and ME. We used spatial analysis to identify clusters of census block groups with statistically significant high incidence. Results We identified 11 clusters of statistically significant high incidence, each containing 6 or more cases of ALS. These 11 clusters are grouped in 4 distinct regions. Conclusions There appear to be areas of significant spatial clustering within Northern New England. Further analysis will be needed to confirm whether there is any correlation between these areas and potential environmental risk factors. Muscle Nerve, 48: 235–241, 2013 REFERENCES 1 Cronin S, Hardiman O, Traynor BJ. Ethnic variation in the incidence of ALS: a systematic review. 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