Experiments relating to the mechanism of death cap poisoning
1965; Elsevier BV; Volume: 3; Issue: 1 Linguagem: Inglês
10.1016/0041-0101(65)90066-8
ISSN1879-3150
AutoresO. Peczenik, Iris Fisher, M. Librus,
Tópico(s)Insect and Pesticide Research
ResumoMethanol extracts taken up in water were prepared from the toadstools Amanita phalloides, Amanita verna, the non-toxic Amanita ovoidea and the toxic Lepiota brunneoincarnata (1 ml being equivalent to 100 mg dried plant). Extracts were compared with phalloidin in their actions on mice. Animals receiving an intraperitoneally lethal dose of phalloidin or of the extracts from A. phalloides or A. verna showed central nervous excitation which was followed by paralysis and death. Excitation was more pronounced in mice receiving these extracts than in those receiving phalloidin; it was absent in mice poisoned with the Lepiota extract. Phalloidin and d-amphetamine acted synergistically. The lethal effect of phalloidin was delayed in mice pretreated with reserpine and reduced in those pretreated with chlorpromazine or perphenazine. Phalloidin toxicity was significantly reduced by combined pretreatment with dexamethasone and glucose.
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