INCREASED ALDOSTERONE SECRETION INDUCED BY SULPIRIDE
1980; Wiley; Volume: 13; Issue: 1 Linguagem: Inglês
10.1111/j.1365-2265.1980.tb01016.x
ISSN1365-2265
AutoresG. Costa, N Frisina, R. De Pasquale,
Tópico(s)Adrenal Hormones and Disorders
ResumoSUMMARY Sulpiride induces an increase in plasma prolactin and a simultaneous increase of aldosterone release in man. In isolated and superfused bovine adrenal glands, prolactin does not increase aldosterone production even in high concentrations, whereas sulpiride induces a significant and long lasting increase in the production of this hormone and a concomitant increase in the tissue levels of cAMP. This suggests a direct effect on the biosynthesis of aldosterone.
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