IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans
2014; National Academy of Sciences; Volume: 111; Issue: 9 Linguagem: Inglês
10.1073/pnas.1322831111
ISSN1091-6490
AutoresAntonella De Luca, Sanne P. Smeekens, Andrea Casagrande, Rossana G. Iannitti, Kara L. Conway, Mark S. Gresnigt, Jakob Begun, Theo S. Plantinga, Leo A. B. Joosten, J.W.M. van der Meer, Georgios Chamilos, Mihai G. Netea, Ramnik J. Xavier, Charles A. Dinarello, Luigina Romani, Frank L. van de Veerdonk,
Tópico(s)Inflammasome and immune disorders
ResumoSignificance Chronic granulomatous disease (CGD) has an immunodeficiency component and, in addition, an autoinflammatory component in which autophagy and inflammasome activation are linked and amenable to IL-1 blockade. This study provides a rationale to perform clinical trials to investigate the efficacy of blocking IL-1 in CGD colitis and expands the therapeutic potential of IL-1 antagonists to inflammatory diseases with defective autophagy.
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