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Goblet Cell Mimickers in Esophageal Biopsies Are Not Associated With an Increased Risk for Dysplasia

2007; American Medical Association; Volume: 131; Issue: 4 Linguagem: Inglês

10.1043/1543-2165(2007)131[571

1543-2165

Mamoun Younes, Atilla Ertan, Gulchin A. Ergun, Ray Verm, Margaret Bridges, Karen Woods, Frank V. Meriano, A. Carl Schmulen, Ronald Colman, Craig Johnson, Alberto Barroso, Jim T. Schwartz, John C. McKechnie, Juan Lechago,

Gastrointestinal Tumor Research and Treatment

Abstract Context.—Identification of intestinal-type goblet cells (ITGCs) in hematoxylin-eosin–stained sections of esophageal biopsies is essential for the diagnosis of Barrett metaplasia. However, we have seen cases diagnosed as Barrett metaplasia based solely on cells that pose morphologic similarity to ITGCs on hematoxylin-eosin staining or stain positive with Alcian blue. Objective.—To determine the clinical significance of goblet cell mimickers. Design.—Initial biopsies from 78 patients with original diagnosis of Barrett metaplasia negative for dysplasia and a mean follow-up of 72 months were reviewed and reclassified into 3 categories: (1) ITGCs, (2) goblet cell mimickers, or (3) neither. Sections from available paraffin blocks were stained with Alcian blue at pH 2.5. The presence of the different types of cells and positive Alcian blue staining were correlated with each other and evaluated for their significance as predictors of progression to dysplasia. Results.—Goblet cell mimickers were present i...