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E119D Neuraminidase Mutation Conferring Pan-Resistance to Neuraminidase Inhibitors in an A(H1N1)pdm09 Isolate From a Stem-Cell Transplant Recipient

2015; Oxford University Press; Volume: 212; Issue: 11 Linguagem: Inglês

10.1093/infdis/jiv288

1537-6613

Arnaud G. L’Huillier, Yacine Abed, Tom J. Petty, Samuel Cordey, Yves Thomas, Xavier Bouhy, Manuel Schibler, Audrey Simon, Yves Chalandon, Christian van Delden, Evgeny M. Zdobnov, P. Boquete-Suter, Guy Boivin, Laurent Kaiser,

Trypanosoma species research and implications

Background. An influenza A(H1N1)pdm09 infection was diagnosed in a hematopoietic stem cell transplant recipient during conditioning regimen. He was treated with oral oseltamivir, later combined with intravenous zanamivir. The H275Y neuraminidase (NA) mutation was first detected, and an E119D NA mutation was identified during zanamivir therapy.