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Acetylsalicylic acid and morphology of red blood cells

2010; Instituto de Tecnologia do Paraná (Tecpar); Volume: 53; Issue: 3 Linguagem: Inglês

10.1590/s1516-89132010000300010

1678-4324

Jacques Natan Grinapel Frydman, Adenilson de Souza da Fonseca, Vanessa Câmara da Rocha, Mônica Oliveira Benarroz, Gabrielle de Souza Rocha, Márcia de Oliveira Pereira, Mário José dos Santos Pereira, Aldo Cunha Medeiros, Mário Bernardo-Filho,

Hormonal and reproductive studies

This work evaluated the effect of in vitro and in vivo treatment with ASA on the morphology of the red blood cells. Blood samples or Wistar rats were treated with ASA for one hour. Blood samples or animals treated with saline were used as control group. Blood smears were prepared, fixed, stained and the qualitative and quantitative morphology of red blood cells were evaluated under optical microscopy. Data showed that the in vitro treatment for one hour with ASA at higher dose used significantly (p<0.05) modified the perimeter/area ratio of the red blood cells. No morphological alterations were obtained with the in vivo treatment. ASA use at highest doses could interfere on shape of red blood cells.