Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2
2002; American Association for the Advancement of Science; Volume: 298; Issue: 5595 Linguagem: Inglês
10.1126/science.1075565
ISSN1095-9203
AutoresArya Biragyn, Pier Adelchi Ruffini, Cynthia A. Leifer, Elena N. Klyushnenkova, Aleksander M. Shakhov, Oleg Chertov, Aiko K. Shirakawa, Joshua Μ. Farber, David M. Segal, Joost J. Oppenheim, Larry W. Kwak,
Tópico(s)Immunotherapy and Immune Responses
Resumobeta-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine beta-defensin 2 (mDF2beta) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.
Referência(s)