Alternating Antipyretics: Antipyretic Efficacy of Acetaminophen Versus Acetaminophen Alternated With Ibuprofen in Children
2008; SAGE Publishing; Volume: 47; Issue: 9 Linguagem: Inglês
10.1177/0009922808319967
ISSN1938-2707
AutoresLynne C. Kramer, Peaches A. Richards, Amy Thompson, David P. Harper, Mary Fairchok,
Tópico(s)Pediatric Pain Management Techniques
ResumoMethods A prospective, randomized double-blind placebo control study comparing the efficacy of acetaminophen to acetaminophen alternated with ibuprofen in 38 healthy outpatient children 6 months to 6 years presenting to the outpatient clinic with fever >38°C was conducted. Temperatures were recorded at 0, 3, 4, 5, and 6 hours. Side effect diaries and parental perception of efficacy were filled out hourly by parents. Results There were no significant differences in temperature between the 2 groups at times 0, 3, and 6 hours. The alternating group had significantly lower mean temperatures at both 4 hours (38.0°C vs 37.4°C; P = .05) and 5 hours (37.1°C vs 37.9°C; P = .0032). Parents did not perceive any difference in fever control between the groups. Conclusions An alternating regimen of acetaminophen with ibuprofen significantly decreased fever at 4 and 5 hours compared with acetaminophen alone. However, parents did not perceive a difference in efficacy.
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