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Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediation

2010; Taylor & Francis; Volume: 6; Issue: 2 Linguagem: Inglês

10.1517/17425250903431040

1744-7607

Santosh Kumar,

Biochemical and Molecular Research

Importance of the field: Cytochrome P450 enzymes comprise a superfamily of heme monooxygenases that are of considerable interest for the: i) synthesis of novel drugs and drug metabolites; ii) targeted cancer gene therapy; iii) biosensor design; and iv) bioremediation. However, their applications are limited because cytochrome P450, especially mammalian P450 enzymes, show a low turnover rate and stability, and require a complex source of electrons through cytochrome P450 reductase and NADPH.