Comparison of Two Methods for Measuring Drug-Induced Neurotoxicity
1969; Elsevier BV; Volume: 58; Issue: 7 Linguagem: Inglês
10.1002/jps.2600580730
ISSN1520-6017
Autores Tópico(s)Neuroscience and Neural Engineering
ResumoA series of experiments is described in which a rotating and a stationary rod procedure were used to determine the neurotoxic effect of various depressant and antidepressant agents in mice and rats. The results of these studies revealed that the rotating rod technique is more sensitive in detecting drug-induced changes in performance. Observed differences between the two methods were more striking in mice than in rats. A series of experiments is described in which a rotating and a stationary rod procedure were used to determine the neurotoxic effect of various depressant and antidepressant agents in mice and rats. The results of these studies revealed that the rotating rod technique is more sensitive in detecting drug-induced changes in performance. Observed differences between the two methods were more striking in mice than in rats.
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