Acid-Free Aza Diels−Alder Reaction of Danishefsky's Diene with Imines
2002; American Chemical Society; Volume: 4; Issue: 19 Linguagem: Inglês
10.1021/ol0265822
ISSN1523-7060
AutoresYu Yuan, Xin Li, Kuiling Ding,
Tópico(s)Advanced Synthetic Organic Chemistry
Resumo[reaction: see text] A highly efficient aza Diels-Alder reaction of Danishefsky's diene with imines was found to occur in methanol in the absence of any acids at room temperature to give corresponding 2-substituted dihydro-4-pyridone derivatives in high yields. This reaction can be also carried out in a three-component one-pot reaction manner. The reaction was found to proceed through a Mannich-type condensation mechanism.
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