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Healthy twins delivered after oocyte cryopreservation and bilateral ovariectomy for ovarian cancer

2008; Elsevier BV; Volume: 17; Issue: 2 Linguagem: Inglês

10.1016/s1472-6483(10)60204-0

1472-6491

Eleonora Porcu, Stefano Venturoli, Giuseppe Damiano, PM Ciotti, Leonardo Notarangelo, Roberto Paradisi, Massimo Moscarini, Guido Ambrosini,

Ovarian function and disorders

Anti-neoplastic treatments have significantly increased the survival of cancer patients, but female patients risk premature menopause. Oocyte cryopreservation has been proposed as a fertility-saving option. This report describes the first live birth achieved with autologous cryopreserved oocytes in an ovariectomized borderline cancer patient. A patient with a borderline ovarian tumour asked for oocyte cryopreservation after a right adnexectomy. Ovulation induction resulted in the retrieval and cryopreservation of seven mature oocytes. Thirty-nine months after a left ovariectomy, the patient asked for oocyte thawing and embryo transfer. Endometrial growth was induced using hormone replacement treatment. Three of the seven cryopreserved oocytes were thawed; they survived and, after insemination, normal fertilization took place. Three embryos were transferred into the patient's uterus. A twin pregnancy was achieved with the birth of two healthy females. Oocyte cryopreservation may be a reliable option for preserving fertility in young cancer patients who risk premature menopause due to surgery, chemotherapy or radiotherapy.