Voltar
Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Comparative Analysis of Anti-Hepatitis C Virus Activity and Gene Expression Mediated by Alpha, Beta, and Gamma Interferons

2002; American Society for Microbiology; Volume: 76; Issue: 21 Linguagem: Inglês

10.1128/jvi.76.21.11148-11154.2002

ISSN

1098-5514

Autores

I. Wayne Cheney, Vicky C. H. Lai, Weidong Zhong, Tessa Brodhag, Shannon Dempsey, Charmaine Lim, Zhi Hong, Johnson Y. N. Lau, Robert C. Tam,

Tópico(s)

Viral Infections and Immunology Research

Resumo

A direct comparison of the inhibitory effects of alpha, beta, and gamma interferons (IFNs) on replication of a hepatitis C virus subgenomic replicon in a hepatoma cell line revealed similarities in antiviral potency. However, alternate IFN-induced antiviral mechanisms were suggested following observations of striking differences between IFN-gamma and IFN-alpha/beta with respect to strength and durability of the antiviral response and the magnitude and pattern of IFN-mediated gene expression.

Referência(s)