Portal de Periódicos da CAPES

Intracerebral propagation of Alzheimer's disease: Strengthening evidence of a herpes simplex virus etiology

2012; Wiley; Volume: 9; Issue: 2 Linguagem: Inglês

10.1016/j.jalz.2012.07.005

1552-5279

Melvyn J. Ball, Walter J. Lukiw, Eli M. Kammerman, James M. Hill,

RNA regulation and disease

A faulty human protein, abnormally phosphorylated tau, was recently publicized to spread "like a virus" from neuron to neuron in Alzheimer's patients' brains. For several decades, we have been amassing arguments showing that herpes simplex virus type 1 (HSV-1), not p-tau, propagates this interneuronal, transsynaptic pathologic cascade.