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Survival of women with cancers of breast and genital organs in Europe 1999–2007: Results of the EUROCARE-5 study

2015; Elsevier BV; Volume: 51; Issue: 15 Linguagem: Inglês

10.1016/j.ejca.2015.07.022

1879-0852

Milena Sant, María Dolores Chirlaque López, Roberto Agresti, María‐José Sánchez, Bernd Holleczek, Magdalena Bielska‐Lasota, Nadya Dimitrova, Kaire Innos, Alexander Katalinic, Hilde Langseth, Nerea Larrañaga, Silvia Rossi, Sabine Siesling, Pamela Minicozzi, Monika Hackl, N. Zielonke, Willi Oberaigner, E. Van Eycken, K. Henau, Z. Valerianova, Nadya Dimitrova, Mario Šekerija, Miroslav Zvolský, Ladislav Dušek, Hans H. Storm, Gerda Engholm, Margit Mägi, Tiiu Aareleid, Nea Malila, Karri Seppä, Michel Velten, X. Troussard, Véronique Bouvier, Guy Launoy, A.V. Guizard, Jean Faivre, Anne‐Marie Bouvier, P. Arveux, Marc Maynadié, Anne‐Sophie Woronoff, Michel Robaszkiewicz, Isabelle Baldi, Alain Monnereau, Brigitte Trétarre, Nadine Bossard, Aurélien Belot, Marc Colonna, F. Molinié, S. Bara, C. Schvartz, B. Lapôtre‐Ledoux, Pascale Grosclaude, M. Meyer, Roland Stabenow, Sabine Luttmann, Andrea Eberle, Hermann Brenner, Alice Nennecke, Jutta Engel, G. Schubert-Fritschle, Joachim Kieschke, Jan Heidrich, Bernd Holleczek, Alexander Katalinic, Jón G. Jónasson, Laufey Tryggvadóttír, Harry Comber, Guido Mazzoleni, A. Bulatko, Carlotta Buzzoni, Adriano Giacomin, A. Sutera Sardo, Pamela Mancuso, Stefano Ferretti, Emanuele Crocetti, Adele Caldarella, Gemma Gatta, Milena Sant, H. Amash, C. Amati, Paolo Baili, Franco Berrino, S. Bonfarnuzzo, Laura Botta, F. Di Salvo, Roberto Foschi, C. Margutti, E. Meneghini, Pamela Minicozzi, Annalisa Trama, Diego Serraino, Luigino Dal Maso, Roberta De Angelis, M. Caldora, Riccardo Capocaccia, E. Carrani, Silvia Francisci, Sandra Mallone, Daniela Pierannunzio, P. Roazzi, Silvia Rossi, Mariano Santaquilani, Andrea Tavilla, Fabio Pannozzo, S. Busco, L Bonelli, Marina Vercelli, Valerio Gennaro, Paolo Ricci, M. Autelitano, Giorgia Randi, Maurizio Ponz de Leòn, C. Marchesi, Claudia Cirilli, Mario Fusco, M.F. Vitale, M. Usala, A. Traina, R. Staiti, Francesco Vitale, Barbara Ravazzolo, Maria Michiara, ­Rosario ­Tumino, Paolo Giorgi Rossi, E. Di Felice, Fabio Falcini, Antonio Iannelli, O. Sechi, R. Cesaraccio, Silvano Piffer, A Madeddu, F. Tisano, S. Maspero, A.C. Fanetti, Roberto Zanetti, Stefano Rosso, P. Candela, T. Scuderi, Fabrizio Stracci, Fortunato Bianconi, Giovanna Tagliabue, Paolo Contiero, Angelo Paolo Dei Tos, Stefano Guzzinati, Santa Pildava, Giedrė Smailytė, Neville Calleja, D. Agius, T.B. Johannesen, Jadwiga Rachtan, Stanisław Góźdż, Ryszard Mężyk, Jerzy Błaszczyk, Marek Bębenek, Magdalena Bielska‐Lasota, G. Forjaz de Lacerda, María José Bento, Clara Castro, A. Miranda, A. Mayer-da-Silva, Florian Nicula, Daniela Coza, C. Safaei Diba, Maja Primic‐Žakelj, E. Almar, C. Ramírez, M. Errezola, J. Bidaurrazaga, A. Torrella-Ramos, J.M. Díaz García, R. Jimenez-Chillaron, Rafael Marcos‐Gragera, À. Izquierdo, María‐José Sánchez, D.Y.L. Chang, Carmen Navarro, María‐Dolores Chirlaque, C. Moreno-Iribas, Eva Ardanáz, Jaume Galcerán, Marià Carulla, Mats Lambe, S. Khan, Seyed Mohsen Mousavi, Christine Bouchardy, M. Usel, S.M. Ess, H. Frick, Matthias Lorez, S.M. Ess, C. Herrmann, Andrea Bordoni, Alessandra Spitale, Isabelle Konzelmann, Otto Visser, V. Lemmens, Michel P. Coleman, Claudia Allemani, Bernard Rachet, Julia Verne, N. Easey, Gill Lawrence, Teresa Morán, Jem Rashbass, M. Roche, J. Wilkinson, Anna Gavin, David Donnelly, David Brewster, Dyfed Huws, Peter D. White, R. Otter,

Colorectal Cancer Screening and Detection

Survival differences across Europe for patients with cancers of breast, uterus, cervix, ovary, vagina and vulva have been documented by previous EUROCARE studies. In the present EUROCARE-5 study we update survival estimates and investigate changes in country-specific and over time survival, discussing their relationship with incidence and mortality dynamics for cancers for which organised screening programs are ongoing.We analysed cases archived in over 80 population-based cancer registries in 29 countries grouped into five European regions. We used the cohort approach to estimate 5-year relative survival (RS) for adult (⩾15years) women diagnosed 2000-2007, by age, country and region; and the period approach to estimate time trends (1999-2007) in RS for breast and cervical cancers.In 2000-2007, 5-year RS was 57% overall, 82% for women diagnosed with breast, 76% with corpus uteri, 62% with cervical, 38% with ovarian, 40% with vaginal and 62% with vulvar cancer. Survival was low for patients resident in Eastern Europe (34% ovary-74% breast) and Ireland and the United Kingdom [Ireland/UK] (31-79%) and high for those resident in Northern Europe (41-85%) except Denmark. Survival decreased with advancing age: markedly for women with ovarian (71% 15-44years; 20% ⩾75years) and breast (86%; 72%) cancers. Survival for patients with breast and cervical cancers increased from 1999-2001 to 2005-2007, remarkably for those resident in countries with initially low survival.Despite increases over time, survival for women's cancers remained poor in Eastern Europe, likely due to advanced stage at diagnosis and/or suboptimum access to adequate care. Low survival for women living in Ireland/UK and Denmark could indicate late detection, possibly related also to referral delay. Poor survival for ovarian cancer across the continent and over time suggests the need for a major research effort to improve prognosis for this common cancer.