Oxidosqualene Cyclase Residues that Promote Formation of Cycloartenol, Lanosterol, and Parkeol
2000; Wiley; Volume: 39; Issue: 22 Linguagem: Inglês
10.1002/1521-3773(20001117)39
ISSN1521-3773
AutoresMichelle M. Meyer, Michael J. R. Segura, William K. Wilson, Seiichi P. T. Matsuda,
Tópico(s)Lipid metabolism and biosynthesis
ResumoA sterol biosynthetic intermediate from sea cucumbers is parkeol (1). By mutation of residues at two positions, the enzyme lanosterol synthase was changed enough to make parkeol as its major product, along with lanosterol (2) and lanost-24-ene-3β,9α-diol (3) as by-products.
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