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Antiparasitic, Antineuroinflammatory, and Cytotoxic Polyketides from the Marine Sponge Plakortis angulospiculatus Collected in Brazil

2008; American Chemical Society; Volume: 71; Issue: 3 Linguagem: Inglês

10.1021/np0705256

1520-6025

M. H. Kossuga, Andréa Mendes do Nascimento, Juliana Quero Reimão, André G. Tempone, Noemi Nosomi Taniwaki, Katyuscya Veloso, Antônio G. Ferreira, Bruno C. Cavalcanti, Cláudia Pessoa, Manoel Odorico de Moraes, Alejandro M. S. Mayer, Eduardo Hajdu, Roberto G. S. Berlinck,

Marine Sponges and Natural Products

Investigation of the bioactive crude extract from the sponge Plakortis angulospiculatus from Brazil led to the isolation of plakortenone (1) as a new polyketide, along with five known polyketides (2–6) previously isolated from other Plakortis sponges. The known polyketides were tested in antileishmanial, antitrypanosomal, antineuroinflammatory, and cytotoxicity assays. The results show that plakortide P (3) is a potent antiparasitic compound, against both Leishmania chagasi and Trypanosona cruzi, and exhibited antineuroinflammatory activity. The known polyketides 2−6 were tested for cytotoxicity against four human cancer cell lines, but displayed only moderate cytotoxic activity.