Portal de Periódicos da CAPES

The mechanism of spindle assembly

2004; Rockefeller University Press; Volume: 166; Issue: 7 Linguagem: Inglês

10.1083/jcb.200312112

1540-8140

Oliver J. Gruß, Isabelle Vernos,

RNA Research and Splicing

Recent work has provided new insights into the mechanism of spindle assembly. Growing evidence supports a model in which the small GTPase Ran plays a central role in this process. Here, we examine the evidence for the existence of a RanGTP gradient around mitotic chromosomes and some controversial data on the role that chromosomes play in spindle assembly. We review the current knowledge on the Ran downstream targets for spindle assembly and we focus on the multiple roles of TPX2, one of the targets of RanGTP during cell division.