Produção Nacional
Revisado por pares
The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms
2014; Instituto Oswaldo Cruz, Ministério da Saúde; Volume: 109; Issue: 3 Linguagem: Inglês
10.1590/0074-0276130496
ISSN1678-8060
AutoresPolicarpo Ademar Sales, Celso de Oliveira Rezende Júnior, Mireille Le Hyaric, Mauro V. de Almeida, Álvaro J. Romanha,
Tópico(s)Synthesis and Biological Evaluation
ResumoFour diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi. Two of these compounds (6 and 7) showed better activity against both proliferative stages of T. cruzi than the positive control benznidazole, three were of similar potency (1, 2 and 5) and two were less active (3 and 4).
Referência(s)