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Tetramethylpyridiniumporphyrazines—a new class of G-quadruplex inducing and stabilising ligands

2006; Royal Society of Chemistry; Issue: 45 Linguagem: Inglês

10.1039/b611731g

1364-548X

Diana P. N. Gonçalves, Raphaël Rodriguez, Shankar Balasubramanian, Jeremy K. M. Sanders,

Advanced biosensing and bioanalysis techniques

3,4-Tetramethylpyridiniumporphyrazines bind strongly and selectively to human telomeric G-quadruplex DNA, inducing the formation of an antiparallel quadruplex in a process that mimics molecular chaperones.