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Recent advances in the genetics of primary immunodeficiency syndromes

1996; Elsevier BV; Volume: 129; Issue: 1 Linguagem: Inglês

10.1016/s0022-3476(96)70184-1

1097-6833

Shyh‐Dar Shyur, Harry R. Hill,

Respiratory viral infections research

Recurrent infections or a severe infection in a patient should suggest to the clinician the possibility of an underlying immunodeficiency. Early diagnosis of an immune disorder could prevent a number of serious consequences including live virus vaccine-induced complications such as poliomyelitis, the development of chronic lung disease, local suppurative infections, and overwhelming and sometimes fatal viral or bacterial infection. Moreover, timely diagnosis of an index case can provide the opportunity for subsequent genetic counseling, carrier detection, prenatal diagnosis, and prompt institution of immunotherapy. For these reasons, it is important for practicing pediatricians to maintain a high index of suspicion of immunodeficiency.