Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC Autopsy Research Report
1986; American Psychiatric Association; Volume: 143; Issue: 7 Linguagem: Inglês
10.1176/ajp.143.7.862
ISSN1535-7228
AutoresEdward Ritvo, B. J. Freeman, Arnold B. Scheibel, Tanya T. Duong, H. Herbert Robinson, D. Guthrie, Anne Ritvo,
Tópico(s)Congenital heart defects research
ResumoBack to table of contents Previous article Next article No AccessLower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC Autopsy Research ReportPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.143.7.862AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractAs part of an autopsy research project, the brains of four autistic subjects were examined and compared with those of three comparison subjects without CNS pathology and one with phenytoin toxicity. The cerebellum was selected for initial investigation because pathognomonic symptoms and neurophysiological measures suggest that pathology may exist in the cerebellar-vestibular axis in certain patients. Total Purkinje cell counts were significantly lower in the cerebellar hemisphere and vermis of each autistic subject than in the comparison subjects. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byDifferential Effects of Developmental Cerebellar Abnormality on Cognitive and Motor Functions in the Cerebellum: An fMRI Study of AutismGreg Allen, Ph.D., and Eric Courchesne, Ph.D.1 February 2003 | American Journal of Psychiatry, Vol. 160, No. 2Delayed maturation of the frontal cortex in childhood autism1 April 2006 | American Journal of Psychiatry, Vol. 152, No. 2Magnetic resonance imaging of the posterior fossa in autistic adults1 April 2006 | American Journal of Psychiatry, Vol. 149, No. 2The UCLA-University of Utah epidemiologic survey of autism: the etiologic role of rare diseases1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 12Magnetic resonance imaging evidence for a defect of cerebral cortical development in autism1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 6The UCLA-University of Utah epidemiologic survey of autism: recurrence risk estimates and genetic counseling1 April 2006 | American Journal of Psychiatry, Vol. 146, No. 8A magnetic resonance imaging study of autism: normal fourth ventricle size and absence of pathology1 April 2006 | American Journal of Psychiatry, Vol. 146, No. 4Seasonal cocaine abuse1 April 2006 | American Journal of Psychiatry, Vol. 146, No. 4Positron emission tomography of the cerebellum in autism1 April 2006 | American Journal of Psychiatry, Vol. 146, No. 2Electroretinograms in autism: a pilot study of b-wave amplitudes1 April 2006 | American Journal of Psychiatry, Vol. 145, No. 2 Volume 143Issue 7 July 1986Pages 862-866 Metrics PDF download History Published online 1 April 2006 Published in print 1 July 1986
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