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Taxane-Mediated Antiangiogenesis in Vitro

2004; American Association for Cancer Research; Volume: 64; Issue: 3 Linguagem: Inglês

10.1158/0008-5472.can-03-3391

1538-7445

Sylvia S. W. Ng, William D. Figg, Alex Sparreboom,

Cancer, Lipids, and Metabolism

Abstract Paclitaxel (Taxol) and docetaxel (Taxotere) have been shown to inhibit angiogenesis at low concentrations that do not affect cancer cell proliferation. Here, we used rat aortic rings and human umbilical vein endothelial cells to evaluate the influence of their formulation vehicles Cremophor EL and polysorbate 80, as well as serum binding proteins on taxane-mediated antiangiogenesis. The data show that clinically relevant concentrations of the vehicles and binding proteins nullify the antiangiogenic activity of both taxanes. It is suggested that these agents may need to be used at much higher doses than anticipated for effective antiangiogenic chemotherapy.