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NIR‐Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene‐Modified Mesoporous Silica

2013; Wiley; Volume: 52; Issue: 16 Linguagem: Inglês

10.1002/anie.201300183

1521-3773

Jianan Liu, Wenbo Bu, Limin Pan, Jianlin Shi,

Luminescence Properties of Advanced Materials

Photomediated drug release: Silica-coated upconverting nanoparticles with mesopores modified by azobenzene molecules were synthesized. The azobenzene molecules make possible the release of the anticancer drug doxorubicin from the pore network of the mesoporous silica outer layer by irradiation with near-infrared (NIR) laser light. The release is regulated by the trans–cis photoisomerization of the azobenzene molecules (see picture). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.