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Hypoglycaemic action of stevioside and a barley and brewer’s yeast based preparation in the experimental model on mice

2011; Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina; Volume: 11; Issue: 1 Linguagem: Inglês

10.17305/bjbms.2011.2616

1840-4812

Vlada Cekic, Velibor Vasović, Vida Jakovljevič, Momir Mikov, Ana Sabo,

Biochemical effects in animals

Th e aim of this study was to investigate infl uence of the preparation based on barley and brewer' s yeast extracts with chromium (BBCr) and stevioside (S) on fasting glycaemia and glycaemia in mice after glucose, adrenalin and alloxan application.Th e animals were divided into three groups: glucose  mgkg - (I); adrenalin . mgkg - (II) and alloxan  mg kg - (III) and into subgroups according to the substance they received: stevioside  mg kg - (I-S, II-S, III-S); BBCr  mg kg - (I-BBCr, II-BBCr, III-BBCr) and saline ml/g (III-placebo).Glycaemia was measured before and after -day treatment with stevioside or BBCr in the following conditions: fasting, min after glucose load (I) or min after adrenaline load (II).In group III glycaemia was measured before and after -day treatment with S, BBCr or placebo and alloxan application ( th ,  th and  th days of treatment ).BBCr signifi cantly reduced fasting glycaemia in I and II groups and glycaemia values after the glucose load (I-BBCr: . ± . vs. .± . mmol/L, p = .).Stevioside signifi cantly reduced glycaemia after the adrenalin load (II-S: . ± . vs. .± . mmol/L; p = .).In the III-BBCr glycaemia values did not indicate the development of alloxan-induced diabetes and were signifi cantly lower than in the III-placebo (. ± . vs. .± . mmol/L; p < .).In conclusion, BBCr caused a signifi cant decrease of fasting glycaemia, signifi cant reduction of glycaemia after glucose load and prevented onset of alloxan-induced diabetes.Stevioside caused the decrease of adrenalin-induced hyperglycaemia.