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The Genome Sequence of Trypanosoma cruzi , Etiologic Agent of Chagas Disease

2005; American Association for the Advancement of Science; Volume: 309; Issue: 5733 Linguagem: Inglês

10.1126/science.1112631

1095-9203

Najib M. El-Sayed, Peter J. Myler, Daniella Castanheira Bartholomeu, Daniel Nilsson, Gautam Aggarwal, Anh-Nhi Tran, Elodie Ghedin, Elizabeth A. Worthey, Arthur L. Delcher, Gaëlle Blandin, Scott J Westenberger, Elisabet Caler, Gustavo Cerqueira, Carole Branche, Brian J. Haas, Atashi Anupama, Erik Arner, Lena Åslund, Philip Attipoe, Esteban J. Bontempi, Frédéric Bringaud, Peter Burton, Eithon Cadag, David A. Campbell, Mark Carrington, Jonathan Crabtree, Hamid Darban, José Franco da Silveira, Pieter de Jong, Kimberly M. Edwards, Paul T. Englund, Gholam Fazelina, Tamara V. Feldblyum, Marcela Ferella, Alberto C.C. Frasch, Keith Gull, David Horn, Lihua Hou, Yi‐Ting Huang, Ellen Kindlund, Michele M. Klingbeil, Sindy Kluge, Hean Koo, Daniela R. Lacerda, Mariano J. Levin, Hernán Lorenzi, Tin Louie, Carlos Renato Machado, Richard McCulloch, Alan Mckenna, Yumi Mizuno, Jeremy C. Mottram, Siri Nelson, Stephen Ochaya, Kazutoyo Osoegawa, Grace Pai, Marilyn Parsons, Martin Pentony, Ulf Pettersson, Mihai Pop, José Luis Ramı́rez, Joel Rinta, Laura Robertson, Steven L. Salzberg, Daniel O. Sánchez, Amber Seyler, Reuben Sunil Kumar Sharma, Jyoti Shetty, Anjana J. Simpson, Ellen Sisk, Martti T. Tammi, Rick L. Tarleton, Santuza Maria Ribeiro Teixeira, Susan Van Aken, Christy Vogt, Pauline N. Ward, Bill Wickstead, Jennifer R. Wortman, Owen White, Claire M. Fraser, Kenneth Stuart, Björn Andersson,

Biochemical and Molecular Research

Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei , and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.