The Molecular Physiology of Tight Junction Pores
2004; American Physiological Society; Volume: 19; Issue: 6 Linguagem: Inglês
10.1152/physiol.00027.2004
ISSN1548-9213
AutoresChristina M. Van Itallie, James M. Anderson,
Tópico(s)Caveolin-1 and cellular processes
ResumoTight junctions form selective barriers that regulate paracellular transport across epithelia. A large family of tetraspanning cell-cell adhesion proteins called claudins create the barrier and regulate electrical resistance, size, and ionic charge selectivity. Study of inherited human claudin diseases and the outcome of the genetic manupulation of claudins in mice, Drosophila, and Caenorhabditis elegans are furthering our understanding of paracellular physiology.
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