The gas chromatography mass spectrometry of the major metabolites of flurazepam
1977; Wiley; Volume: 4; Issue: 4 Linguagem: Inglês
10.1002/bms.1200040411
ISSN2376-3876
AutoresA.J. Clatworthy, L. V. Jones, Martin J. Whitehouse,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoBiomedical Mass SpectrometryVolume 4, Issue 4 p. 248-254 Article The gas chromatography mass spectrometry of the major metabolites of flurazepam A. J. Clatworthy, A. J. Clatworthy The Metropolitan Police Forensic Science Laboratory, 109 Lambeth Road, London SE1 7LP, EnglandSearch for more papers by this authorL. V. Jones, L. V. Jones The Metropolitan Police Forensic Science Laboratory, 109 Lambeth Road, London SE1 7LP, EnglandSearch for more papers by this authorM. J. Whitehouse, M. J. Whitehouse The Metropolitan Police Forensic Science Laboratory, 109 Lambeth Road, London SE1 7LP, EnglandSearch for more papers by this author A. J. Clatworthy, A. J. Clatworthy The Metropolitan Police Forensic Science Laboratory, 109 Lambeth Road, London SE1 7LP, EnglandSearch for more papers by this authorL. V. Jones, L. V. Jones The Metropolitan Police Forensic Science Laboratory, 109 Lambeth Road, London SE1 7LP, EnglandSearch for more papers by this authorM. J. Whitehouse, M. J. Whitehouse The Metropolitan Police Forensic Science Laboratory, 109 Lambeth Road, London SE1 7LP, EnglandSearch for more papers by this author First published: August 1977 https://doi.org/10.1002/bms.1200040411Citations: 17AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Mass spectra and gas chromatographic data are presented for flurazepam and its metabolites; monodesethyl flurazepam, didesethylflurazepam, hydroxyethylflurazepam, N1-desalkylflurazepam, N1-desalkyl-3-hydroxy flurazepam, and flurazepam-N1-acetic acid. The on-column thermal degradation of didesethylflurazepam, N1-desalkyl-3-hydroxyflurazepam and flurazepam-N1-acetic acid is reported and discussed. Mass spectrometric and gas chromatographic data are also presented for the benzophenones obtained by acid hydrolysis of flurazepam and its metabolites. The occurrence of flurazepam metabolites in urine from five forensic cases after various treatments has been investigated. A possible new 'metabolite' of flurazepam was detected in two of these cases. Citing Literature Volume4, Issue4August 1977Pages 248-254 RelatedInformation
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