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Treatment of Vesicoureteral Reflux by Endoscopic Injection of Dextranomer/Hyaluronic Acid Copolymer: Preliminary Results

2003; Lippincott Williams & Wilkins; Volume: 170; Issue: 4 Part 2 Linguagem: Inglês

10.1097/01.ju.0000083924.44779.80

1527-3792

Prem Puri, Boris Chertin, MURUGESH VELAYUDHAM, LAXAMAN DASS, Eric Colhoun,

Ureteral procedures and complications

No AccessJournal of UrologyCLINICAL UROLOGY: Vesicoureteral Reflux1 Oct 2003Treatment of Vesicoureteral Reflux by Endoscopic Injection of Dextranomer/Hyaluronic Acid Copolymer: Preliminary Results PREM PURI, BORIS CHERTIN, MURUGESH VELAYUDHAM, LAXAMAN DASS, and ERIC COLHOUN PREM PURIPREM PURI , BORIS CHERTINBORIS CHERTIN , MURUGESH VELAYUDHAMMURUGESH VELAYUDHAM , LAXAMAN DASSLAXAMAN DASS , and ERIC COLHOUNERIC COLHOUN View All Author Informationhttps://doi.org/10.1097/01.ju.0000083924.44779.80AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Endoscopic subureteral injection of tissue augmenting substances has become an established alternative to long-term antibiotic prophylaxis and open surgery for the management of vesicoureteral reflux (VUR) in children. Recently, dextranomer/hyaluronic acid copolymer (Deflux, Q-Med AB, Uppsala, Sweden) a biodegradable injectable material has been reported to be a promising alternative to other tissue augmenting substances. However, the experience with dextranomer/hyaluronic acid copolymer is limited. We prospectively evaluate the effectiveness of dextranomer/hyaluronic acid copolymer in the endoscopic treatment of VUR. Materials and Methods: A total of 32 males and 81 females with a median age of 1 year (range 3 months to 10 years) underwent endoscopic correction of primary VUR with dextranomer/hyaluronic acid copolymer. Reflux was unilateral in 58 cases and bilateral in 54, affecting 166 ureters. Reflux was grades II to V in 7 (4.2%) cases, 91 (54.8%), 63 (38%) and 5 (3%), respectively. All patients underwent endoscopic correction as a day procedure and have been followed for 3 months to 1 year. Results: The reflux was corrected in 143 (86%) of the 166 ureters after a single injection, and resolved after a second and third injection in 22 (13%) and 1 (1%) ureter, respectively. No untoward effects were seen in any of these patients with the use of dextranomer/hyaluronic acid copolymer as an injectable material. Conclusions: Dextranomer/hyaluronic acid copolymer is an effective tissue augmenting substance in the endoscopic treatment of all grades of VUR. References 1 : Guidelines for consideration for surgical repair of vesicoureteral reflux. Curr Opin Urol2000; 10: 579. Google Scholar 2 : Vesicoureteric reflux and reflux nephropathy. In: Diseases of the Kidney. Edited by . Boston: Little, Brown & Co.1993: 689. Google Scholar 3 American Urological Association. Report on the management of primary vesicoureteral reflux in children. Baltimore: American Urological Association1997. Google Scholar 4 : Surgical treatment of vesicoureteric reflux. Edited by . 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Volume 170 Issue 4 Part 2 October 2003 Page: 1541-1544 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordshyaluronic acidpolymerendoscopyvesico-ureteral refluxMetrics Author Information PREM PURI More articles by this author BORIS CHERTIN More articles by this author MURUGESH VELAYUDHAM More articles by this author LAXAMAN DASS More articles by this author ERIC COLHOUN More articles by this author Expand All Advertisement PDF downloadLoading ...