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Effects of IL‐12 and Antibodies to IL‐12 on Established Granulomatous Colitis in Mice

1996; Wiley; Volume: 795; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1996.tb52695.x

1749-6632

Markus F. Neurath, Ivan J. Fuss, Brian L. Kelsall, K.‐H. Meyer zum Büschenfelde, Warren Strober,

IL-33, ST2, and ILC Pathways

Annals of the New York Academy of SciencesVolume 795, Issue 1 p. 368-370 Effects of IL-12 and Antibodies to IL-12 on Established Granulomatous Colitis in Mice MARKUS F. NEURATH, Corresponding Author MARKUS F. NEURATH Mucosal Immunity Section National Institutes of Health, NIAID I LCI Rockville Pike Bethesda, Maryland 20892Dr. Markus F. Neurath, Mucosal Immunity Section, National Institutes of Health, N1H/NIAID/LCI, Building 10; Room 11N238, Rockville Pike, Bethesda, MD 20892-1890; Fax: 301 402 2240.Search for more papers by this authorIVAN FUSS, IVAN FUSS Mucosal Immunity Section National Institutes of Health, NIAID I LCI Rockville Pike Bethesda, Maryland 20892Search for more papers by this authorBRIAN KELSALL, BRIAN KELSALL Mucosal Immunity Section National Institutes of Health, NIAID I LCI Rockville Pike Bethesda, Maryland 20892Search for more papers by this authorK.-H. MEYER zum BÜSCHENFELDE, K.-H. MEYER zum BÜSCHENFELDE Mucosal Immunity Section National Institutes of Health, NIAID I LCI Rockville Pike Bethesda, Maryland 20892Search for more papers by this authorWARREN STROBER, WARREN STROBER Mucosal Immunity Section National Institutes of Health, NIAID I LCI Rockville Pike Bethesda, Maryland 20892Search for more papers by this author MARKUS F. NEURATH, Corresponding Author MARKUS F. NEURATH Mucosal Immunity Section National Institutes of Health, NIAID I LCI Rockville Pike Bethesda, Maryland 20892Dr. Markus F. Neurath, Mucosal Immunity Section, National Institutes of Health, N1H/NIAID/LCI, Building 10; Room 11N238, Rockville Pike, Bethesda, MD 20892-1890; Fax: 301 402 2240.Search for more papers by this authorIVAN FUSS, IVAN FUSS Mucosal Immunity Section National Institutes of Health, NIAID I LCI Rockville Pike Bethesda, Maryland 20892Search for more papers by this authorBRIAN KELSALL, BRIAN KELSALL Mucosal Immunity Section National Institutes of Health, NIAID I LCI Rockville Pike Bethesda, Maryland 20892Search for more papers by this authorK.-H. MEYER zum BÜSCHENFELDE, K.-H. MEYER zum BÜSCHENFELDE Mucosal Immunity Section National Institutes of Health, NIAID I LCI Rockville Pike Bethesda, Maryland 20892Search for more papers by this authorWARREN STROBER, WARREN STROBER Mucosal Immunity Section National Institutes of Health, NIAID I LCI Rockville Pike Bethesda, Maryland 20892Search for more papers by this author First published: October 1996 https://doi.org/10.1111/j.1749-6632.1996.tb52695.xCitations: 29AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Podolsky, D. K. 1991. Inflammatory bowel disease. N. Engl. J. Med. 325: 928– 936. 2 Strober, W. & M. F. Neurath. 1995. Immunological diseases of the gastrointestinal tract. In R. R. Rich, Ed. Clinical Immunology. Chapter 94. Mosby. St. Louis . 3 Hammer, R. E., S. D. Maika, J. A. Richardson, Y. P. Tang & J. D. Taurog. 1990. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β32m: An animal model of HLAB-27-associated human disorders. Cell 63: 1099– 1109. 4 Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller & I. Horvak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253– 262. 5 Kühn, R., J. Lohler, D. Rennick, K. Rajewsky & W. Möller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75: 263– 277. 6 Rudolph, U., M. J. Finegold, S. S. Rich, G. R. Harriman, Y. Srinivasan, P. Brabet, G. Boulay, A. Bradley & L. Birnbaumer. 1995. Ulcerative colitis and adenocarcinoma of the colon in Gα12-deficient mice. Nature Gen. 10: 143– 149. 7 Mombaerts, P., E. Mizoguchi, M. J. Grusby, L. H. Glimcher, A. K. Bahn & S. Tonegawa. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75: 275– 288. 8 Powrie, F., M. W. Leach, S. Mauze, S. Menon, L. B. Caddle & R. L. Coffman. 1994. Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1: 553– 565. 9 Neurath, M. F., I. Fuss, B. L. Kelsall, E. Stuber & W. Strober. 1995. Antibodies to IL-12 abrogate established experimental colitis in mice. J. Exp. Med. 182: 1281– 1290. Citing Literature Volume795, Issue1Interleukin 12: Cellular and Molecular Immunology of an Important Regulatory CytokineOctober 1996Pages 368-370 ReferencesRelatedInformation