A Mystery Featuring Right-to-Left Shunting Despite Normal Intracardiac Pressure
2005; Elsevier BV; Volume: 128; Issue: 2 Linguagem: Inglês
10.1378/chest.128.2.998
ISSN1931-3543
AutoresMario Zanchetta, Alberto Rigatelli, Siew Yen Ho,
Tópico(s)Congenital Heart Disease Studies
ResumoThe cause of right-to-left atrial shunting despite normal intracardiac pressures and normal or near-normal pulmonary function through a patent foramen ovale has still not been completely clarified. It is probably responsible for several linked diseases, such as paradoxical embolism, platypnea-orthodeoxia syndrome, migraine with aura, transient global amnesia, and decompression sickness in sport divers. Despite modern diagnostic methods, the underlying anatomophysiologic and pathogenic mechanisms of right-to-left atrial shunting without abnormal intracardiac pressures remain a matter of debate and controversy. Holistically speaking, a return to a direct study of embryology, gross anatomy, and physiology may help us elucidate the real mechanism of this paradoxical shunting
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