Tumor necrosis factor alpha acts as an autocrine second signal with gamma interferon to induce nitric oxide in group B streptococcus-treated macrophages
1995; American Society for Microbiology; Volume: 63; Issue: 9 Linguagem: Inglês
10.1128/iai.63.9.3715-3717.1995
ISSN1098-5522
AutoresK J Goodrum, Julie Dierksheide, Brian J. Yoder,
Tópico(s)Neutrophil, Myeloperoxidase and Oxidative Mechanisms
ResumoNitric oxide production by mouse macrophages treated with group B streptococci and gamma interferon was inhibited by cytochalasin B or by antibody neutralization of macrophage-derived tumor necrosis factor alpha. Phagocytosis-induced tumor necrosis factor alpha is responsible for group B streptococcus-induced nitric oxide production in interferon-treated macrophages.
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