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Antimycobacterial compounds. New pyrrole derivatives of BM212

2004; Elsevier BV; Volume: 12; Issue: 6 Linguagem: Inglês

10.1016/j.bmc.2003.12.037

1464-3391

Mariangela Biava, Giulio Cesare Porretta, Delia Deidda, Raffaello Pompei, Andrea Tafi, Fabrizio Manetti,

Biochemical and Molecular Research

We have identified BM212 as a lead compound among a series of pyrrole derivatives with good in vitro activity against mycobacteria and candidae. First studies led us to synthesize some pyrrole compounds in which the thiomorpholine fragment was present. Some compounds revealed very active and these findings prompted us to prepare new pyrrole derivatives 2-15 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria.