Synthesis of cholesterol-polyamine carbamates: pKa studies and condensation of calf thymus DNA
1998; Royal Society of Chemistry; Issue: 13 Linguagem: Inglês
10.1039/a803284j
ISSN1364-548X
AutoresAndrew J Geall, Ian S. Blagbrough, Andrew J. Geall, Richard J. K. Taylor, Mark Earll, Michael A. W. Eaton,
Tópico(s)DNA and Nucleic Acid Chemistry
ResumoNovel cholesterol-polyamine carbamates have been prepared and their pKas determined potentiometrically for conjugates substituted with up to five amino functional groups and the binding affinity for calf thymus DNA has also been determined; these polyamine carbamates are models for lipoplex formation with respect to gene delivery (lipofection), a key first step in gene therapy.
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