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Gene transfer to the rat kidney in vivo and ex vivo using an adenovirus vector: factors influencing transgene expression

2005; Oxford University Press; Volume: 20; Issue: 7 Linguagem: Inglês

10.1093/ndt/gfh783

1460-2385

Jun Fujishiro, Shin’ichi Takeda, Yuichi Takeno, Koichi Takeuchi, Yukiyo Ogata, Masafumi Takahashi, Yoji Hakamata, Takashi Kaneko, Takashi Murakami, Takashi Okada, Keiya Ozawa, Kohei Hashizume, Eiji Kobayashi,

Xenotransplantation and immune response

Background. The characteristics of adenovirus-mediated gene transfer into the kidney are not well examined. We studied the effects of contact time and temperature on adenovirus-mediated transgene expression in rat kidneys, using catheter-based in vivo gene transfer and a rat renal transplant model ex vivo.