Portal de Periódicos da CAPES

Structure-Function Relationships of the G Domain, a Canonical Switch Motif

2011; Annual Reviews; Volume: 80; Issue: 1 Linguagem: Inglês

10.1146/annurev-biochem-062708-134043

1545-4509

Alfred Wittinghofer, Ingrid R. Vetter,

Enzyme Structure and Function

GTP-binding (G) proteins constitute a class of P-loop (phosphate-binding loop) proteins that work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The common principle is the 160-180-residue G domain with an α,β topology that is responsible for nucleotide-dependent conformational changes and drives many biological functions. Although the G domain uses a universally conserved switching mechanism, its structure, function, and GTPase reaction are modified for many different pathways and processes.