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BIBTEX RIS

Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)

2009; Brazilian Chemical Society; Volume: 32; Issue: 5 Linguagem: Inglês

10.1590/s0100-40422009000500026

ISSN

1678-7064

Autores

Fernando R. Pavan, Clarice Queico Fujimura Leite, Roberta Gomes Coelho, Isabel Duarte Coutinho, Neli Kika Honda, Cláudia Andréa Lima Cardoso, Wagner Vilegas, Luís Eduardo Coelho Andrade, Daisy Nakamura Sato,

Tópico(s)

Papaya Research and Applications

Resumo

The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.

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