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Left ventricular intrinsic contractility in pure rheumatic mitral stenosis

1989; Elsevier BV; Volume: 64; Issue: 3 Linguagem: Inglês

10.1016/0002-9149(89)90469-4

1879-1913

Jagdish C. Mohan, Mohammed Khalilullah, Ramesh Arora,

Cardiac electrophysiology and arrhythmias

The status of left ventricular (LV) intrinsic contractile function in isolated rheumatic mitral stenosis (MS) is an unsettled issue. Although the overall LV ejection performance is reduced in a number of patients with MS,1–3 it is a product of interaction between intrinsic contractility, preload and afterload. Although intrinsic LV contractility in MS has been found to be normal in 2 studies,3,4 other investigators, using methods still to be validated, found it to be decreased.5,6 Recently, reliable load-independent indexes of intrinsic contractility have been validated and applied in clinical studies. These are end-systolic pressure or end-systolic meridian wall stress to end-systolic volume or dimension ratio7 and fractional fiber shortening to end-systolic stress relations.8 We assessed LV intrinsic myocardial contractile function as measured by the aforementioned methods in patients with isolated rheumatic MS.