Portal de Periódicos da CAPES

Probing Dynamics within Amyloid Fibrils Using a Novel Capping Method

2009; Wiley; Volume: 48; Issue: 31 Linguagem: Inglês

10.1002/anie.200901343

1521-3773

Geoffrey W. Platt, Wei‐Feng Xue, Steve W. Homans, Sheena E. Radford,

Advanced Neuroimaging Techniques and Applications

Twist and shout: Dynamics within amyloid fibrils are probed using solution NMR spectroscopy (see 1H–15N HSQC NMR spectra of wild-type β2-microglobulin and a variant with an extended N-terminal region). A novel method is employed to ensure the origin of NMR signals and to take molecular recycling from fibrils into account. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.