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The short-term bronchodilator effects of fenoterol and ipratropium in asthma

1982; Elsevier BV; Volume: 69; Issue: 5 Linguagem: Inglês

10.1016/0091-6749(82)90123-3

1097-6825

R. Kevin Elwood, R. T. ABBOUD,

Pharmacological Effects and Assays

We studied the bronchodilator effects of inhaled,fenoterol, a relatively selective beta-2 adrenergic agent, and ipratropium an anticholinergic drug, singly and in combination in IO patients with asthma.The period of observation was 6 hr after aerosol administration.The six drug regimens used were fenoterol 100 t.Lg, fenoterol 200 Fg, fenoterol 50 pg combined with 20 t.Lg of ipratropium, fenoterol 100 t.Lg combined with 40 pg of ipratropium, 40 kg of ipratropium, and placebo.Measurements consisted of spirometry with determination of forced expiratory volume in one second (FEV,), maximal expiratory jlow at 50% of vital capacity (VsO), specific airway conductance, lung volumes, and heart rate.Bronchodilation with regimens containing fenoterol was rapid, with 7570 of the maximum response achieved by 5 min, while the peak effect of ipratropium was delayed for I to 2 hr.Fenoterol 100 pg produced approximately half the degree of improvement in FEV, and V,, compared with 200 p,g of fenoterol.The addition of 40 pg of ipratropium to 100 Fg of fenoterol resulted in bronchodilation equivalent to 200 pg fenoterol and was associated with a more prolonged effect than fenoterol 100 pg.Tremor was observed in two subjects inhaling fenoterol200 pg but was not observed with any other regimen.It is concluded that the combination of inhaled ipratropium and fenoterol is an effective bronchodilator in asthma, achieving efficacy similar to that of fenoterol alone but with,fewer side effects.(