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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Premature ovarian failure (POF) in Brazilian fragile X carriers

1999; Brazilian Society of Genetics; Volume: 22; Issue: 4 Linguagem: Inglês

10.1590/s1415-47571999000400002

ISSN

1678-4685

Autores

Angela Maria Vianna‐Morgante, Silvia Souza da Costa, Rita de Cássia M. Pavanello, Paulo Alberto Otto, Regina Célia Mingroni‐Netto,

Tópico(s)

Congenital heart defects research

Resumo

The gynecological and reproductive histories of 193 women from fragile X families were surveyed. Among the 101 carriers of the premutation, 14 experienced premature menopause, contrarily to their 37 fully mutated and 55 noncarrier female relatives. Although premature menopause showed a tendency to cluster in certain fragile X families, as a group, the premutated women experienced menopause earlier than noncarriers. This suggests that premature menopause may be the extreme effect of a spectrum of ovarian anomalies associated with the fragile X premutation.

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