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The Emergence of Rotavirus G12 and the Prevalence of Enteric Viruses in Hospitalized Pediatric Diarrheal Patients in Southern Vietnam

2011; American Society of Tropical Medicine and Hygiene; Volume: 85; Issue: 4 Linguagem: Inglês

10.4269/ajtmh.2011.11-0364

1476-1645

My V. T. Phan, Maia A. Rabaa, Ha Vinh, Edward C. Holmes, Nguyễn Văn Minh Hoàng, Ha Vinh, Lê Thị Phượng, Nguyễn Thị Thắm, Phan Van Be Bay, James I. Campbell, Jeremy Farrar, Stephen Baker,

Viral Infections and Immunology Research

Diarrhea is a major cause of childhood morbidity and mortality in developing countries, and the majority of infections are of viral etiology. We aimed to compare the etiological prevalence of the major enteric viruses in an urban and a rural setting in southern Vietnam. We simultaneously screened fecal specimens from 362 children in Ho Chi Minh City and Dong Thap province that were hospitalized with acute diarrhea over a 1-month-long period for four viral gastrointestinal pathogens. Rotavirus was the most common pathogen identified, but there was a differential prevalence of rotavirus and norovirus between the urban and rural locations. Furthermore, rotavirus genotyping and phylogenetic analysis again differentiated the genotypes by the sampling location. Our data show a disproportional distribution of enteric viral pathogens in urban and rural locations, and we provide evidence of continual importation of new rotavirus strains into southern Vietnam and report the emergence of rotavirus genotype G12.